PUBLICATIONS

32. M. Huang, Y. Chen, C. Liang, O. Narayan, C. Stallings, M. Yu, C. Traugot, L. Li, K. Li, Q. Vo, H. Wang, Y.-T. Chou, L. Cech, D. Parra, L. Garzon, D. Parsons, E. Diaz, C. Zhang, C. Mackey, H. Sussman, I. Zmirska, M. Chung, C. Zhou, G. Glynatsis, D.W. Siemann, J.D. Licht, C. Li, F.J. Kaye, M. Xie, Y. Tan, L. Wu, T.G. Bivona*, J. Guan*, X. Tang*. Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability. Biomaterials 329, 123920 (2025). LINK

31. K. Scheller, X. Zhou, K. Li, L. Jiang, R. Ochoa, P. Cossio, L. Wu, J. Guan*. Trimerization domain-interfering peptide inhibits EML4-ALK condensate formation, fusion-dependent signaling, and cell growth. MBoC 36:br25, 1 (2025). LINK

30. Z. Shen, X. Yang, G. Seabra, X. Xu, J. Dong, J.O. Brant, W. Zhou, J. Guan, W. Jiang, C. Li. Discovery and Mechanism of 16–19F, a Novel Synthetic Lethal Inhibitor of the PRMT5• MTA Complex in MTAP-Deleted Cancer Cells. ACS Chem. Biol. 20, 1333 (2025). LINK

29. C. Mackey, Y. Feng, C. Liang, A. Liang, H. Tian, O.P. Narayan, J. Dong, Y. Tai, J. Hu, Y. Mu, Q. Vo, L. Wu, D. Siemann, J. Pan, X. Yang, K. Huang, T. George, J. Guan*, X. Tang*. Mechanical Modulation, Physiological Roles, and Imaging Innovations of Intercellular Calcium Waves in Living Systems. Cancers 17, 1851 (2025). LINK

28. M.C. Chung, H.R. Mendez-Gomez, D. Soni, R. McGinley, A. Zacharia, J. Ashbrook, B. Stover, A.J. Grippin, E.J. Sayour, J. Guan*. Multi-Step assembly of an RNA-liposome nanoparticle formulation revealed by real-time, single-particle quantitative imaging. Adv. Sci. 2025, 2414305 (2025). LINK

27. O. Narayan, J. Dong, M. Huang, L. Chen, L. Liu, V. Nguyen, A.V. Dozic, X. Liu, H. Wang, Q. Yin, X. Tang, J. Guan*. Reversible light-responsive protein hydrogel for on-demand cell encapsulation and release. Acta Biomater. 193, 202 (2025). LINK

26. D. Gonzalez-Martinez, L. Roth, T.R. Mumford, J. Guan, A. Le, R.C Doebele, B. Huang, A. Tulpule, M. Niewiadomska-Bugaj, T.G. Bivona, L.J. Bugaj. Oncogenic EML4-ALK assemblies suppress growth factor perception and modulate drug tolerance. Nature Commun 15, 9473 (2024). LINK

25. H.R. Mendez-Gomez, A. DeVries, P. Castillo, C. von Roemeling, S. Qdaisat, B.D. Stover, C. Xie, F. Weidert, C. Zhao, R. Moor, R. Liu, D. Soni, E. Ogando-Rivas, J. Chardon-Robles, J. McGuiness, D. Zhang, M.C. Chung, C. Marconi, S. Michel, A. Barpujari, G.W. Jobin, N. Thomas, X. Ma, Y. Campaneria, A. Grippin, A. Karachi, D. Li, B. Sahay, L. Elliott, T.P. Foster, K.E. Coleman, R.J. Milner, W.G. Sawyer, J.A. Ligon, E. Simon, B. Cleaver, K. Wynne, M. Hodik, A.M. Molinaro, J. Guan, P. Kellish, A. Doty, J.-H. Lee, T. Massini, J.L. Kresak, J. Huang, E.I. Hwang, C. Kline, S. Carrera-Justiz, M. Rahman, S. Gatica, S. Mueller, M. Prados, A.P. Ghiaseddin, N.L. Silver, D.A. Mitchell, E.J. Sayour. RNA aggregates harness the danger response for potent cancer immunotherapy. Cell 187, 2521-2535 (2024). LINK

Spotlight Article: Beyond the danger signal: RNA aggregates orchestrate immunotherapy, Trends in Molecular Medicine, 30, 702.

24. F. Haderk, Y.-T. Chou, L. Cech, C. Fernández-Méndez, J. Yu, V. Olivas, I.M Meraz, D.B. Rabago, D.L. Kerr, C. Gomez, D.V. Allegakoen, J. Guan, K.N. Shah, K.A. Herrington, O.M. Gbenedio, S. Nanjo, M. Majidi, W. Tamaki, Y.K. Pourmoghadam, J.K. Rotow, C.E. McCoach, J.W. Riess, J.S. Gutkind, T.T. Tang, L. Post, B. Huang, P. Santisteban, H. Goodarzi, S. Bandyopadhyay, C.J. Kuo, J.P. Roose, W. Wu, C.M. Blakely, J.A. Roth, T.G. Bivona. Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Nature Commun 15, 3741 (2024). LINK

23. T.R. Mumford, D. Rae, E. Brackhahn, A. Idris, D. Gonzalez-Martinez, A.A. Pal, M.C. Chung, J. Guan, E. Rhoades, L.J. Bugaj. Simple visualization of submicroscopic protein clusters with a phase-separation-based fluorescent reporter. Cell Systems 15, 166-179 (2024). LINK

22. M. Huang, H. Wang, C. Mackey, M.C. Chung, J. Guan, G. Zheng, A. Roy, M. Xie, C. Vulpe, X. Tang. YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer. Int J Mol Sci. 24, 12491 (2023). LINK

21. Q. Luo, J. Zhang, M. Huang, G. Lin, M. Tanaka, S. Lepler, J. Guan, D. Siemann, X. Tang. Automatic Multi-functional Integration Program (AMFIP) towards All-optical Mechano-electrophysiology Interrogation. Plos One 17(7): e0266098 (2022). LINK

20. M. Huang, H. Wang, A.A. Delgado, T.A. Reid, J. Long, S. Wang, H. Sussman, J. Guan, H. Yamaguchi, X. Tang. Combining 3D Magnetic Force Actuator and Multi-functional Fluorescence Imaging to Study Nucleus Mechanobiology. J. Vis. Exp. (185), e64098 (2022). LINK

19. A. Tulpule#, J. Guan#, D. Neel#, H.R. Allegakoen, Y.P. Lin, D. Brown, Y.T. Chou, A. Heslin, N. Chatterjee, S. Perati, S. Menon, T. Nguyen, J. Debnath, A.D. Ramirez, X. Shi, B. Yang, S. Feng, S. Makhija, B. Huang, T.G. Bivona. Kinase-mediated RAS Signaling via Membraneless Cytoplasmic Protein Granules. Cell 184, 1-16 (2021). (#co-first author) LINK

Spotlight Article: Oncogenic Signaling of RTK Fusions Becomes More Granular, Molecular Cell, 81, 2504.
Research Watch: RTKs Can Form Membraneless Granules to Drive Cytoplasmic RAS Signaling, Cancer discover, 11, 1316.

18. T.M. Zeigler, M.C. Chung, O. Narayan, J. Guan*. Protein phase separation: physical models and phase-separation-mediated cancer signaling. Advances in physics: X. 6, 1936638 (2021). LINK

17. M.C. Chung, D. Liao, J. Guan*. Protein phase separation in cell death and survival. Mechanisms of Cell Death and Opportunities for Therapeutic Development, Chapter 6, 175-195. Academic Press. (2021). LINK

16. Q. Luo, M. Huang, C. Liang, J. Zhang, G. Lin, S. Yu, M. Tanaka, S. Lepler, J. Guan, D. Siemann, X. Tang. All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System. J. Vis. Exp. 178, e62934 (2021). LINK

15. J. Alexander, J. Guan, B. Li, L. Maliskova, M. Song, Y. Shen, B. Huang, S. Lomvardas, O.D. Weiner. Live-Cell Imaging Reveals Enhancer-dependent Sox2 Transcription in the Absence of Enhancer Proximity. eLife 8, e41769 (2019). LINK

14. M. Percharde, C.J. Lin, Y. Yin, J. Guan, G.A. Peixoto, A. Bulut-Karslioglu, S. Biechele, B. Huang, X. Shen, M. Ramalho-Santos. A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity. Cell 174, 391 (2018). LINK

Preview Article: A lncRNA-like Role for LINE1s in Development, Developmental Cell, 46, 132.

13. T. Chow, X. Shi, J. Wei, J. Guan, G. Stadler, B. Huang, E. H. Blackburn. Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection. Nat. Commun. 9, 3583 (2018). LINK

12. J. Guan, K. Chen, A. Y. Jee, S. Granick. DNA molecules deviate from shortest trajectory when driven through hydrogel. J. Chem. Phys. 149, 163331 (2018). LINK

11. J. Guan, H. Liu, X. Shi, S. Feng, B. Huang. Tracking multiple genomic elements using correlative CRISPR imaging and sequential DNA FISH. Biophys. J. 112, 1077 (2017). LINK

Highlighted as “New and Notable”: FISHing Out the Details of CRISPR Genome Tracks, Biophysical Journal, 112, 1045.

10. B. Chen*, J. Guan*, B. Huang*. Imaging Specific Genomic DNA in Living Cells. Annu. Rev. Biophys. 45, 1 (2016). LINK

9. J. Guan, B. Wang, S. Granick. Even Hard-Sphere Colloidal Suspensions Display Fickian Yet Non-Gaussian Diffusion. ACS Nano 8, 3331 (2014). LINK

8. J. Guan, B. Wang, S.C. Bae, S. Granick. Modular Stitching to Image Single-Molecule DNA Transport. J. Am. Chem. Soc. 135, 6006 (2013). LINK

7. C. Yu, J. Guan, K. Chen, S.C. Bae, S. Granick. Single-Molecule Observation of Long Jumps in Polymer Adsorption. ACS Nano 7, 9735 (2013). LINK

6. K. Chen, B. Wang, J. Guan, S. Granick. Diagnosing Heterogeneous Dynamics in Single Molecule/Particle Trajectories with Multiscale Wavelets. ACS Nano 7, 8634 (2013). LINK

Perspective Article: Revealing Hidden Dynamics within Living Soft Matter, ACS Nano, 7, 8333–8339.

5. J. Guan, B. Wang, S. Granick. Automated Single Molecule Tracking of DNA Shape. Langmuir 27, 6149 (2011). LINK

4. S. Granick, S.C. Bae, B. Wang, S. Kumar, J. Guan, C. Yu, K. Chen, J. Kuo. Single-molecule Methods in Polymer Science. J. Polym. Sci. Part B Polym. Phys. 48, 2542 (2010). LINK

3. X. Ye, J. Fei, J. Guan, X. Zhou, G., Zhang. Dispersion of Polystyrene Inside Polystyrene-b-poly (N-isopropylacrylamide) Micelles in Water. J. Polym. Sci. Part B Polym. Phys. 48, 749 (2010). LINK

2. B. Wang, J. Guan, S. M. Anthony, S.C. Bae, K.S. Schweizer, S. Granick. Confining Potential When a Biopolymer Filament Reptates. Phys. Rev. Lett. 104, 118301 (2010). LINK

Editor's suggestions

1. S. Marre, J. Park, J. Rempel, J. Guan, M. G. Bawendi, K. F. Jensen. Supercritical continuous-microflow synthesis of narrow size distribution quantum dots. Adv. Mater 20, 4830 (2008). LINK